NucleoSyn, leading supplier of innovative DNA & RNA related products and synthetic lipids, launches new product line & services dedicated to support your bioanalytical, Omics and ADME/DMPK projects: Stable Isotope Labeled (SIL) Compounds.
Stable Isotope Labeled Compounds used as:
Tracers in metabolism and omic studies using mass spectrometry or NMR spectroscopy.
Internal standards in quantitative bioanalysis by LC / MS.
Tools to enhance PK of drugs, drug candidates (Deuterium medicinal chemistry).
Tracers for assessing absolute bioavailibility of drug candidate.
Either with 2H, 15N or 13C or a combination of them,
Incorporation of isotopic labels at specific positions of the compound, including site selective and multiple site selective schemes.
For stable isotope dilution assays, preferred labeled isotopes : 15N & 13C (Golden Standard) over 2H lab in order to ensure optimum co-elution with the unlabeled analytes and optimum isotopic purity.
Custom 2H, 13C, 15N building blocks and reagents synthesis.
Experience of labeling a wide range of chemotypes: heterocycle, natural product, amino acid & peptides.